Terbutaline is used for the prevention and reversal of bronchospasm in patients 12 years of age and older with reversible, obstructive airway disease, as well as symptomatic management of reversible bronchospasm associated with bronchitis and emphysema. Guaiphenesin elicits an action to facilitate productive cough to manage chest congestion. Menthol mediates anesthetic properties and anti-irritating properties locally, thus it is widely used to relieve minor throat irritations.
Terbutaline Sulphate IP 1.25 mg
Bromhexine Hydrochloride 4 mg
Guaiphenesin IP 50 mg
Syrup
Anticough
This syrup is used in the management of respiratory conditions that are associated with viscid or excessive mucus, and bronchospasm, including: Asthma, Bronchitis, and Chronic Obstructive Pulmonary Disease (COPD).
Guaiphenesin may interact with duloxetine, phenylephrine and albuterol. Terbutaline may interact with beta-blockers, such as atenolol, carteolol, labetalol, metoprolol, nadolol, propranolol, sotalol, carvedilol, timolol and certain diuretics.
Bromhexine Hydrochlorideis a mucolytic agent that helps break down mucus in the airways, making it less viscous and easier to cough up. By thinning and loosening mucus in the airways, bromhexine helps to clear air passages and facilitates more comfortable breathing.
Guaiphenesin is categorized as an expectorant that acts by enhancing the output of phlegm (sputum) and bronchial secretions via decreasing the adhesiveness and surface tension of such material. It may also act as an irritant to gastric vagal receptors, and recruit efferent parasympathetic reflexes that can elicit glandular exocytosis that is comprised of a less viscous mucus mixture.
It is well orally absorbed and volume of distribution is 116L. It is metabolised in liver and is excreted in urine. The half-life is approximately 1 hour.
Terbutaline is a relatively selective beta2-adrenergic bronchodilator that has little or no effect on alpha-adrenergic receptors. Terbutaline appears to have a greater stimulating effect on beta-receptors of the bronchial, vascular, and uterine smooth muscles (beta2 receptors) than on the beta-receptors of the heart (beta1 receptors). This drug relaxes smooth muscle and inhibits uterine contractions, but may also cause some cardiostimulatory effects and CNS stimulation.
Only 30-50% of the drug is absorbed orally. It is mainly excreted in urine with a half-life of 5.5-5.9 hours.
Possible side effects of this combination may include, but are not limited to: Nausea and vomiting, Diarrhea, Stomach upset, Dizziness or headache, Rash, Tremors (particularly with terbutaline as it is a beta agonist), and Palpitations or tachycardia.
Amino acids and vitamin is contraindicated in those patients with a known hypersensitivity to it or any of its ingredients.