Sucralfate Oral Suspension

Each 10 ml contains:
Sucralfate 1 gm
Sucralphate is a muco- protective drug. It is used in the treatment of duodenal ulcers.It is used in combination with other antibiotics to act against helicobactor bacteria . Sucralphate forms the protective layers on the ulcerated tissues and protect them against gastric acid.
  • Gastro- esophageal reflux disease
  • Gastritis
  • in peptic ulcers
  • duodenal ulcers
  • dyspepsia
  • mucositis
  • In stress ulcers

Mechanism of action:

sucralfate forms a complex with protein-rich exudate found on the surface of ulcers. It binds to albumin and fibrinogen preventing blood clot lysis by stomach acid (hydrochloric acid). Sucralfate increases the levels of fibroblast and epidermal growth factors, leading to an increase in prostaglandins at the gastrointestinal tract lining, which promote the healing of gastrointestinal ulcers.

Pharmacokinetics:

absorption: it is absorbed from gastrointestinal tract
Protein binding: it is mainly bound albumin and transferrin.
Excretion:
it is excreted unchanged in the urine.

common side effect:
constipation

serious side efects:
(1) Rashes
(2) dyspnea
(3) difficulty in swallowing
(4) swelling of the face, throat, tongue, or lips

  • It is contraindicated in pregnancy and during breast feeding.
  • Contraindicated in diabetes mellitus.

It is stored in air tight container and at room temperature.

Caution:

keep it reach out of children.