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Ofloxacin, Ornidazole, Itraconazole & Clobetasol Propionate Cream

This cream is a broad-spectrum antimicrobial and anti-inflammatory formulation used topically to treat mixed skin infections, particularly those involving fungi, bacteria, and inflammation.

Each component works synergistically:

Ofloxacin – a fluoroquinolone antibiotic effective against Gram-positive and Gram-negative bacteria.
Ornidazole – an anti-protozoal and antibacterial agent used to treat anaerobic infections.
Itraconazole – a broad-spectrum antifungal used to treat dermatophytosis, candidiasis, and other fungal infections.
Clobetasol Propionate – a potent corticosteroid that reduces inflammation, redness, and itching.

This combination is especially useful in polymicrobial infections with associated inflammation or itching.

  • Composition

    Ofloxacin – 0.75% w/w
    Ornidazole – 2.0% w/w
    Itraconazole – 1.0% w/w
    Clobetasol Propionate – 0.05% w/w
    Cream base – q.s.

  • Release form

    Ointment

  • Category

    Antibacterial | Antifungal | Anti-inflammatory Topical Cream

Indications

  • Fungal skin infections with secondary bacterial infection (e.g., Tinea corporis, Tinea cruris, Tinea pedis)
  • Dermatitis and eczema with superadded infection
  • Seborrheic dermatitis (fungal + inflammatory skin disorder)
  • Intertrigo (inflammation in skin folds, often infected)
  • Infected cuts, wounds, or abrasions
  • Psoriasis or lichen planus with secondary infection (short-term use only under supervision)
  • Mixed microbial skin conditions with itching, redness, inflammation, or discharge

Precautions & Warnings

Avoid prolonged use, especially on sensitive areas like the face, groin, or underarms; keep away from eyes, mouth, and mucous membranes; perform a patch test before use; use during pregnancy or lactation only if prescribed, and avoid in children under 12 unless advised by a doctor.

Side Effects

The product is generally safe for most adults when used as directed. There are no significant disadvantages if used according to the recommended guidelines. However, in some cases, mild side effects such as itching or irritation, dryness, or peeling of the skin may occur.