Clotrimazole Cream

• Clotrimazole is the antimycotic drug and belongs to the class of imidazole derivative
• It has broad spectrum activity
• It is mainly used for vaginal infections
• At low concentration it usually acts as fungistatic and at higher concentration it acts as fungicidal

  • Vaginal yeast infection
  • Athlete’s foot
  • It is used for dermal infections
  • Oropharyngeal candidiasis
  • Systemic mycoses

Mechanism of action:

Clotrimazole changes the permeability of the cell membrane of yeast by inhibiting the ergosterol synthesis by blocking the enzyme 14- alpha demethylase, here ergosterol promotes the growth of the fungal cells so clotrimazole act on it and prevent its biosynthesis.


absorption: It is absorbed by oral administration
Protein binding: It is 98% bound to serum proteins
It is metabolized in the liver.

  • Urticaria
  • Blistering
  • Pruritis
  • Stinging
  • Irritation on the skin
  • Cramps
  • Burning sensation
  • Peeling of the skin

Contraindicated in people with known hypersensitivity

  • Clindamycin
  • Coumarin
  • Dicoumarol
  • Diphenadone
  • Capmatinib