Sodium Picosulfate Oral Solution
Sodium Picosulfate 5 mg
Mechansium Of Action:
sodium picosulfate, is a contact laxative. Sodium picosulfate inhibits the absorption of water and electrolytes, and increases their secretion into the intestinal lumen . It is hydrolyzed by colonic bacterial enzyme, sulfatase , to form an active metabolite bis-(p-hydroxy-phenyl)-pyridyl-2-methane (BHPM), which acts directly on the colonic mucosa to stimulate colonic peristalsis. This compound is a stimulant laxative and increases peristalsis in the gut.
In healthy volunteers receiving 2 packets of sodium picosulfate in combination with magnesium oxide and anhydrous citric acid every 6 hours, the mean peak plasma concentrations (Cmax) of sodium picosulfate was achieved within 7 hours (Tmax) Label. The mean Cmax of its active metabolite, BHPM, was 0.05 ng/mL
Metabolism: Sodium picosulfate is hydrolyzed by colonic bacteria to form an active metabolite bis-(p-hydroxy-phenyl)-pyridyl-2-methane (BHPM)
Elimination: Sodium picosulfate and its metabolite BHPM are mainly excreted in urine. The fraction of the absorbed sodium picosulfate dose excreted in urine as unchanged parent compound was 0.19% Label. Urinary recovery of BHPM was 0.01% of total administered drug Label. A small amount absorbed picosulfate is reported to be excreted in the urine as a glucuronide-conjugate of BHPM
Sodium picosulfate is a stimulant laxative that in conjunction with magnesium citrate, produces a purgative effect on stools. In a multicentre, observational study comprising of patients undergoing colonoscopy, more than 93.0% of the patients receiving sodium picosulfate-containing preparations reported the colon cleansing effect to be effective.
Pregnant: Contact your doctor before taking this.
- Head Pain.
- Stomach Cramps.
- Swelling Of The Abdomen.
- Taste Impairment.