Sertaconazole Dusting Powder

Product description:

This powder is used to treat a variety of fungal skin infections such as ringworm, athlete's foot, and jock itch. It also helps to relieve the itching, burning, cracking, and scaling from these infections. Sertaconazole is an antifungal that works by preventing the growth of fungus.
For the treatment of fungal infections of the skin.

PHARMACOLOGICAL & PHARMACODYNAMIC PROPERTIES:

Sertaconazole is an imidazole/triazole type antifungal agent. Sertaconazole is a highly selective inhibitor of fungal cytochrome P-450 sterol C-14 α-demethylation via the inhibition of the enzyme cytochrome P450 14α-demethylase. This enzyme converts lanosterol to ergosterol, and is required in fungal cell wall synthesis. The subsequent loss of normal sterols correlates with the accumulation of 14 α-methyl sterols in fungi and may be partly responsible for the fungistatic activity of fluconazole. Mammalian cell demethylation is much less sensitive to fluconazole inhibition. Sertaconazole exhibits in vitro activity against Cryptococcus neoformans and Candida spp. Fungistatic activity has also been demonstrated in normal and immunocompromised animal models for systemic and intracranial fungal infections due to Cryptococcus neoformans and for systemic infections due to Candida albicans.

MECHANISM OF ACTION:

Sertaconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Sertaconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.

PHARMACOKINETIC PROPERTIES:

Absorption: There is little absorption through skin or mucous membranes when Sertaconazole is applied topically.
DISTRIBUTION: Absorbed Sertaconazole is bound to plasma proteins (88.2%) and red blood cells (10.6%).
METABOLISM AND EXCRETION: The small amount of Sertaconazole that is absorbed is eliminated predominantly in faeces as both unchanged drug and metabolites.

Contraindicated in patients with known hypersensitivity.
   Though very rare but some of the reported side-effects of this include:
  • Severe itching
  • Redness
  • Burning
  • Blistering
  • Swelling
  • Oozing
  • Irritation of the skin