Promethazine Hydrochloride Suspension

Promethazine HCL Suspension:
A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.
Features of Oral Solution
Accurate composition
Quick results
Less side effect
What is Promethazine HCl Oral Solution?
Promethazine is an antihistamine which can be taken by mouth as an oral solution whose uses are as following:-
  • "Hay fever," or, a stuffy runny nose from allergy.
  • Watery, itchy eyes due to inhaled allergies and foods.
  • Mild allergic skin reactions with itching and swelling.
  • Allergic reactions to blood or plasma.
  • dermographism, a form of hives known as "skin writing".
  • Serious allergic reactions along with epinephrine and other treatments.
  • Sedation before or after surgery, or during childbirth.
  • Prevention and control of nausea and vomiting after surgery.
  • Along with meperidine (demerol) or other pain medicines.
  • Sedation, relief of anxiety, and production of light sleep from which the patient can be easily aroused.
  • Treatment and prevention of motion sickness.


On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
Promethazine hydrochloride is metabolized in the liver, with the sulfoxides of promethazine and N-desmethylpromethazine being the predominant metabolites.
Urinary tract
16-19 hours
Promethazine interacts with the following class of drugs, therefore severe caution must be exercised while co-administering these drugs with promethazine Oral Solution as it may prove to be fatal at some level :-
CNS Depressants Epinephrine Anticholinergics Monoamine Oxidase Inhibitors (MAOI).
Promethazine HCl Oral Solution is contraindicated for use in pediatric patients less than two years of age.
Promethazine HCl Oral Solution is contraindicated in comatose states, and in individuals known to be hypersensitive or to have had an idiosyncratic reaction to promethazine or to other phenothiazines.
Antihistamines are contraindicated for use in the treatment of lower respiratory tract symptoms, including asthma.
Drugs having anticholinergic properties should be used with caution in patients with narrow-angle glaucoma, prostatic hypertrophy, stenosing peptic ulcer, pyloroduodenal obstruction, and bladder-neck obstruction.
Promethazine HCl Oral Solution should be used cautiously in persons with cardiovascular disease or with impairment of liver function.
  • Headache/Dizziness
  • Dry mouth
  • Loss of appetite
  • Tiredness
  • Blurred vision