PCM & Promethazine Suspension

Promethazine is an ethylene derivative of Phenothiazines with potent antihistaminic properties.Promethazine is not used as antipsychotic; it is used as anti-histamine. Promethazine is a H1 receptor blocking agent.
Paracetamol belongs to a group of medicines known as analgesics or pain killer. It is use to relieve mild to moderate pain.
This combination is used for:
  • Pain
  • Allergic rhinitis
  • Allergic conjunctivitis due to inhalant allergens and foods
  • Urticaria
  • Angioedema
  • Hay fever
  • Vasomotor rhinitis
  • Allergies and common cold
  • In surgery (sedative)
  • Hemolytic disease of the newborn
  • Motion sickness.

PHARMACOKINETIC PROPERTIES OF PCM & Promethazine

PROMETHAZINE:
ABSORPTION:
Promethazine is well absorbed from the gastrointestinal tract and shows clinical effects within 20 min after oral administration.
METABOLISM:
Metabolized in liver to sulfoxide of Promethazine and N-demethylpromethamine.
PROTEIN BINDING:
93%
ELIMINATION:
Renal excretion
HALF LIFE:
16-19 hours

PARACETAMOL:
ABSORPTION:
It is readily absorbed from GI tract and achieves peak plasma concentration in 30 to 60 minute. But it is incompletely available to systemic circulation after oral administration due to first pass metabolism.
METABOLISM:
It metabolism extensively by liver and to minor extent by intestine.
PROTEIN BINDING:
10-25%
ELIMINATION:
Urine (85-90%)
HALF LIFE:
2 hours

PHARMACODYNAMIC PROPERTIES OF PCM & Promethazine

Promethazine treats allergic reactions and motion sickness. Also used before and after surgery and other procedures to make you sleepy, control pain, or prevent and control nausea and vomiting.
This medicine may interact with:
  • CNS Depressants
  • MAO inhibitors
  • Epinephrine
  • Anti-cholinergic
Promethazine HCL oral solution is contradicted for use in pediatric patients less than two years of age.
Antihistamines are contraindicated in the treatment of lower respiratory tract symptoms including asthma.
Promethazine HCL is contradicted in condition like Epilepsy, Glaucoma, and prostatic hypertrophy.
Promethazine oral solutions are contradicted in patients who are in coma state and in individual known to be hypersensitive to Promethazine or other Phenothiazines.
  • Burning sensation
  • Sleepiness
  • Hallucination, agitation
  • Nausea, vomiting
  • Stomach pain
  • Convulsions
  • Jaundice
  • Impotence
Oral suspensions are not to be used more than one month after opening.