Miconazole Nitrate & Fluocinolone Acitonide Cream

This combination is used to treat inflammatory symptoms such as itching , redness and infections caused by yeast which is a fungi.

Miconazole nitrate: Miconazole nitrate is an imidazole antifungal agent and It is a wide antifungal spectrum and has some antibacterial activity. It is used to treat athlete's foot or in ring worm infections.
Fluocinolone acitonide: It is a cortecosteriods used to treat itching, redness, dryness, scaling, inflammation, and discomfort in various inflammatory skin conditions. It mainly treats the inflammation of the skin and mucosa .
  • In Skin allergic reactions such as psoriasis, Dermatitis and Rash
  • Swelling
  • Itching and redness of scalp
  • Seborrheic dermatitis
  • Outer ear eczema ,Otitis externa
i. Lichen planus, vulval pruritis
ii. Seborrheic dermatitis
iii. Dermatoses (secondary infected)

Mechanism of action:

Fluocinolone-
it is a glucocorticoid receptor agonist. It works by binding to cytoplasmic glucocorticoid receptors and translocates to the nucleus and where it initiates the transcription and translation of glucocorticoid-responsive genes such as lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from phospholipid membrane and preventing the synthesis of prostaglandins and leukotrienes, which are the mediators of inflammation.
Miconazole-
Miconazole exerts fungicidal or fungistatic action . It inhibits the conversion of Lanosterol to 14 demethyl Lanosterol by inhibiting the enzyme 14 alpha demethylase and impair ergosterol synthesis

Pharmacokinetics:

Miconazole-
Absorption: miconazole is poorly absorbed by oral route of absorbtion.
Protein binding: It is distributed in the body and 88.2% protein bound .
Metabolism: It metabolised in the liver.
Excretion: It is excreted unchanged in urine and faeces.

Fluocinolone-
Absorption: Fluocinolone is absorbed through skin when applied topically.
  • mild itching in the skin
  • Burning sensation
  • Peeling or dryness of the skin
  • Thinning or softening of your skin
  • Swollen hair follicles
  • occurrence of Blisters, Pimples on the skin
  • Swelling of the mouth
  • Skin reactions
  • headache
  • itching in the vagina
  • The formulation is contraindicated in pregnancy
  • it is also contraindicated in known hypersensitivity reactions.
Not to be used by the children under the age of 12 years .
Store at room temperature.