Luliconazole

Luliconazole lotion is an antifungal agent. It works by killing sensitive fungi by interfering with the formation of the fungal cell membrane and weakening it.
Luliconazole is used to treat skin infections such as athlete's foot, jock itch, and ringworm. Luliconazole is an azole antifungal that works by preventing the growth of the fungus.
   It is used for the treatment of:
  • Tinea pedis (athlete’s foot; fungal infection of the skin on the feet and between the toes)
  • Tinea cruris (jock itch; fungal infection of the skin in the groin or buttocks)
  • Tinea corporis (ringworm; fungal infection that causes a red scaly rash on different parts of the body)

PHARMACODYNAMIC PROPERTIES OF LULICONAZOLE

Luliconazole kills the organisms Trichophyton rubrum and Epidermophyton floccosum, most likely by altering their fungal cell membranes. luliconazole is used to inhibit the enzyme lanosterol demethylase. Lanosterol demethylase is needed for the synthesis of ergosterol, which is a major component of the fungus cell membranes.

PHARMACOKINETIC PROPERTIES OF LULICONAZOLE

ABSORPTION:
After administration, absorption is rapid and complete. 
DISTRIBUTION:
Well distributed to various sites, including CNS, saliva, sputum, blister fluid, urine, normal skin, nails, and blister skin. CNS levels of drug approach 50% to 90% of that of serum. Luliconazole is 12% protein-bound. 
EXCRETION:
Primarily excreted via the kidneys. More than 80% of an administered dose is excreted unchanged in the urine. Excretion rate diminishes as renal function decreases.
METABOLISM:
 Luliconazole is primarily metabolized hepatically.

PREGNANCY AND BREAST FEEDING:
Pregnant and lactating mothers should not take any single supplement in higher-than-normal doses unless recommended by a health-care provider for a special condition.

   Though very rare but some of the reported side-effects of this include:
  • Allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • Increased inflammation
  • Redness
  • Pain