Deflazacort Suspension

Deflazacort is a synthetic Glucocorticoid. It is an oxazoline derivative of prednisolone with antiinflammatory and immunosuppressive activity. Deflazacort works by stopping the release of certain chemicals in your body which cause inflammation. It suppresses the immune system and so can be used to treat Autoimmune Disorder.
WHAT IS AUTOIMMUNE DISORDER?
An autoimmune disorder occurs when the body's immune system attacks and destroys healthy body tissue by mistake. Tissues affected by autoimmune attack include lungs, blood, bones, brain, muscles etc.
Deflazacort is a synthetic Glucocorticoid that can be taken orally as suspension and can be used to treat wide variety of diseases. These include:
  • Severe allergic reactions
  • Rheumatoid arthritis, juvenile arthritis, polymyalgia rheumatic
  • Asthma
  • Acute and lymphatic leukemia
  • Cancer of bone marrow
  • Cancer of lymph node
  • Inflammatory eye disorder e.g. optic neuritis
  • Inflammatory disorder of kidney e.g. nephritic syndrome
  • Inflammatory bowel disease e.g. ulcerative colitis
  • Inflammatory skin disorder e.g. pemphigus vulgaris
  • Inflammatory disease of skin and muscle i.e. dermatomyositis
  • Organ transplant
  • Idiopathic thrombocytopenia purpura
  • Sarcoidosis
  • Anemia caused by the immune system attacking red blood cells
  • Duchene's muscular dystrophy
  • Mixed connective tissue disease.

PHARMACOKINETIC PROPERTIES OF DEFLAZACORT

ABSORPTION:
Deflazacort is well absorbed after oral administration and is immediately converted to pharmacological active metabolite by plasma esterase, which achieves peak plasma concentration in 1.5 to 2 hours.
PROTEIN BINDING:
40%
METABOLISM:
Deflazacort metabolize in liver to an active metabolite D-21-OH.
ELIMINATION HALF-LIFE:
1.1 - 1.9 h
ROUTE OF ELIMINATION:
Kidney (70% via urine and 30% through feces)

PHARMACODYNAMIC PROPERTIES OF DEFLAZACORT

Deflazacort is a Glucocorticoid. Its anti-inflammatory and immunosuppressive effects are used in treating various diseases.
Deflazacort can cause fluid and salt retention and so may oppose the effects of following medicine
Antihypertensive medicines used to treat high blood pressure
Diuretics e.g. furosemide.
There may be an increase chance of level of potassium in the blood falling too low (hypokelemia) if Deflazacort is used in combination with any of the following medicines, which can also lowers the amount of potassium in blood:
Acetazolamide
Amphotericin
Loop diuretics e.g. furosemide
Theophyllin
Beta agonists e.g. salbutamol, terbutaline
Contradicted in patients who are receiving immunosuppressive vaccines and who have infections and hypersensitivity.
Deflazacort crosses the placenta which increases the risk of fetal and neonatal adrenal suppression. So, it must be contradicted in pregnancy.
It should not be use in people with widespread infection, unless this is being treated with specific anti-infective.
METABOLIC:
Increased blood sugar, increased appetite and weight gain.
GASTROINTESTINAL:
Indigestion, abnormal bloating, nausea, ulceration in the stomach or intestine, inflammation of pancreas and throat ulcer.
MUSCULOSKELETAL:
Thinning of bones.
SKIN:
pimples, brushing, stretch marks, increased sweating, change in pigmentation and increased hair growth.
CNS: Mood changes including irritability, depression and suicidal thoughts, psychotic reactions, anxiety, confusion, memory loss and sleep disturbance.
HEART:
elevated blood pressure.
MISCELLANEOUS:
Blood clot events and hiccups.