Clobetasol & Combination Cream

This composition is very effective to treat the problems or symptoms associated with skin diseases such inflammation, itching , redness and also to treat bacterial and fungal infections .this combination only use to the treats bacterial infections it is not recommended for viral infections.
  • used in psoriasis
  • dermititis
  • Lichen Planus- it is condition which causes irritation in the nails , mucous membrane etc
  • miconazole nitrate treats vaginal burning , itching caused by the vaginal yeast infection.
  • Neomycin sulphate also reduce the symptoms of hepatic coma.

Clobetasol Propionate:
clobetasol propionate is a cortecosteriod that prevents the inflammation produced by the inflammatory mediators and it widens the blood vessels and and decrease the density of mast cells , activation of eosinophils , decreasing cytokine productions by lymphocytes , monocytes therfore prevent redness and itching produced by the various skin conditions such as eczema, dermatitis and psoriasis.

Neomycin Sulphate:
Neomycin sulphate is aminoglycoside antibiotic. Neomycin sulphate has a bactericidal action against many Gram-negative bacteria but partial activity against Grampositive bacteria. It is used topically in the treatment of infections of the skin, ear, and eye due to susceptible staphylococci and other organisms.

Miconazole Nitrate:
Miconazole nitrate is an imidazole antifungal agent and It is a wide antifungal spectrum and has some antibacterial activity. It is used to treat athlete's foot or in ring worm infections.

Pharmacokinetics:

absorption: clobetasol is absorbed through percutaneous penetration and neomycin sulphate is poorly absorbed in the gastrointestinal tract when orally administered whereas miconazole is topically absorbed through the mucous membrane and skin .
Protein binding: clobetasol propionate is >90 % bound to plasma proteins.
Miconazole is 88.2% bound to plasma proteins.
Distribution: neomycin sulphate is distributed in the tissues and concentrates in the renal cortex.
Metabolism: clobetasol is metablised in the liver and its metabolites are excreted in the bile.
Excretion: clobetasol propionate and neomycin sulphate is excreted by kidneys whereas miconazole nitrate is excreted unchanged through the faeces.

Mechanism of action:

clobetasol propionate acts by blocking the metabolism of arachidonic acid and prevents the formation of inflammatory mediators which causes inflammation whereas neomycin sulphate
interferes with bacterial protein synthesis by binding to 30S ribosomal subunits and miconazole may act by inhibiting the fungal enzyme 14α-sterol demethylase, resulting in a reduced production of ergosterol.
  • Burning Sensation
  • Dryness of the Skin
  • Redness Of the Skin
  • Itching Of Skin
  • Body Pain
  • thinning of the skin, changes in skin pigmentation
  • stretch marks
  • excessive hair growth (hypertrichosis).
  • contraindicated in patients with known hypersenstivity.
Store below 25°C.

Caution:

Keep out of reach of children.

Instructions for Use/Handling:

For external use only.
Patients should be advised to wash their hands after applying the cream .