Cholecalciferol(Vitamin D3) 60,000IU Soft Gelatin Capsules
Each soft gel capsule contains:
Vitamin D3 is a form of Vitamin D. It is also referred to as Cholecalciferol. Cholecalciferol is the raw form of the nutrient that humans obtain through exposure to sunlight. It is the form the nutrient takes after it has been processed for use by the body. It is structurally similar to steroids such as testosterone, cholesterol, and cortisol (though vitamin D3 itself is a secosteroid). Vitamin D is an essential nutrient that plays an important role in calcium metabolism and bone health. In recent years, biomarkers like PTH, calcium absorption have been used to define relevant biological indices of vitamin D nutritional status. Vitamin D3 supports calcium in your body in order to develop and maintain strong bones and healthy teeth.
Vitamin D3 (Cholecalciferol) is indicated in the treatment and prevention of bone disorders including osteomalacia, rickets and so on, which are caused by low levels of vitamin D in the body.
PHARMACODYNAMIC PROPERTIESCholecalciferol (Vitamin D3) is a steroid hormone that has long been known for its important role in regulating body levels of calcium and phosphorus, in mineralization of bone, and for the assimilation of Vitamin A. The classical manifestations of vitamin D deficiency are rickets, which is seen in children and results in bony deformaties including bowed long bones. Deficiency in adults leads to the disease osteomalacia. Both rickets and osteomalacia reflect impaired mineralization of newly synthesized bone matrix, and usually result from a combination of inadequate exposure to sunlight and decreased dietary intake of vitamin D. Common causes of vitamin D deficiency include genetic defects in the vitamin D receptor, severe liver or kidney disease, and insufficient exposure to sunlight. Vitamin D plays an important role in maintaining calcium balance and in the regulation of parathyroid hormone (PTH). It promotes renal reabsorption of calcium, increases intestinal absorption of calcium and phosphorus, and increases calcium and phosphorus mobilization from bone to plasma.
50% to 80%
Within the liver, cholecalciferal is hydroxylated to calcidiol (25-hydroxycholecalciferol) by the enzyme 25-hydroxylase. Within the kidney, calcidiol serves as a substrate for 1-alpha-hydroxylase, yielding calcitriol (1, 25-dihydroxycholecalciferol), the biologically active form of vitamin D3.
Vitamin D is excreted in faeces and urine.
- Diseases and/or conditions resulting in hypercalcaemia and/or hypercalciuria (e.g. myeloma, bone metastases, primary hyperparathyroidism)
- Nephrolithiasis / nephrocalcinosis
- Severe renal impairment and renal failure
- Hypervitaminosis D
- Hypersensitivity to the active substances or to any of the excipients
Vitamin D3 film-coated tablets can be used during breast-feeding. Calcium and vitamin D pass into breast milk. This should be considered when giving additional vitamin D to the child.
- Allergic reactions like c or hives, swelling of the face, lips, or tongue.
- Bone pain
- Increased thirst
- Increased urination
- Irregular heartbeat, high blood pressure
- Unexpected weight loss