Cetirizine Suspension

Cetirizine is an antihistamine used to relieve allergy symptoms such as watery eyes, runny nose, sneezing, hives, itching eyes/nose and itching. It works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction.
Perennial Allergic Rhinitis:Cetirizine Dihydrochloride syrup is indicated for the relief of symptoms associated with perennial allergic rhinitis due to allergens such as dust mites, animal dander and molds in children 6 to 23 months of age. Symptoms treated effectively include sneezing, rhinorrhea, postnasal discharge, nasal pruritus, ocular pruritus, and tearing.
Temporarily relieves these symptoms due to hay fever or other upper respiratory allergies:
  • Runny Nose
  • Sneezing
  • Itchy, Watery Eyes
  • Itching Of The Nose Or Throat
Chronic Urticaria: Cetirizine Dihydrochloride syrup is indicated for the treatment of the uncomplicated skin manifestations of chronic idiopathic urticaria in children 6 months to 5 years of age. It significantly reduces the occurrence, severity, and duration of hives and significantly reduces pruritus.


Absorption: Cetirizine was rapidly absorbed with a time to maximum concentration (Tmax) of approximately 1 hour following oral administration of syrup in adults.
Metabolism: Cetirizine is metabolized to a limited extent by oxidative O-dealkylation to a metabolite with negligible antihistaminic activity. 70% of the administered radioactivity was recovered in the urine and 10% in the feces.
Distribution: The mean plasma protein binding of Cetirizine is 93%, independent of concentration in the range of 25–1000 ng/mL, which includes the therapeutic plasma levels observed.
Elimination: The mean elimination half-life in 146 healthy volunteers across multiple pharmacokinetic studies was 8.3 hours and the apparent total body clearance for Cetirizine was approximately 53 mL/min.

Mechanism of action

There was a small decrease in the clearance of Cetirizine caused by a 400-mg dose of theophylline; it is possible that larger theophylline doses could have a greater effect.

  • Cetirizine Dihydrochloride is contraindicated in those patients with a known hypersensitivity to it or any of its ingredients or hydroxyzine.
  • Use not recommended in pregnant and lactating mothers until and unless advised by the doctor.
  • Hives
  • Difficult breathing
  • Swelling of your face, lips, tongue or throat

  • Ask a doctor before use if you have liver or kidney disease. Your doctor should determine if you need a different dose.
  • Ask a doctor or pharmacist before use if you are taking tranquilizers or sedatives.
  • In clinical trials, the occurrence of somnolence has been reported in some patients taking Cetirizine Dihydrochloride; due caution should therefore be exercised when driving a car or operating potentially dangerous machinery.