Bromhexine HCL,Guaiphenesin & Dextromethorphan HBR Soft Gel Capsules

Our product comprises of Bromhexine HCl, Guaifenesin and Dextromethorpharn HBr. Bromhexine Hydrochloride is a mucolytic agent. Dextromethorphan Hydrobromide is an antitussive drug. Guaiphenesin is an expectorant.
Temporary relief of coughs and upper respiratory tract symptoms, including nasal congestion, associated with allergy or common cold.

PHARMACODYNAMIC PROPERTIES OF BROMHEXINE HCL

Bromhexine is a synthetic derivative of the herbal active ingredient vasicine. Preclinically, it has been shown to increase the proportion of serous bronchial secretion. Bromhexine enhances mucus transport by reducing mucus viscosity and by activating the ciliated epithelium

PHARMACOKINETIC PROPERTIES OF BROMHEXINE HCL

ABSORPTION:
Bromhexine is rapidly and completely absorbed from the gastrointestinal tract.
DISTRIBUTION:
After intravenous administration bromhexine was rapidly and widely distributed throughout the body with a mean volume of distribution (Vss) of up to 1209 ± 206 L (19 L/kg).
METABOLISM:
Bromhexine is almost completely metabolised to a variety of hydroxylated metabolites and to dibromanthranilic acid. All metabolites and bromhexine itself are conjugated most probably in form of N-glucuronides and O-glucuronides.

PHARMACODYNAMIC PROPERTIES OF GUAIFENESIN

Guaifenesin has an expectorant action which increases the output of respiratory tract fluid by reducing adhesiveness and surface tension. The increased flow of less viscid secretions promotes ciliary action and facilitates the removal of mucus. This changes an unproductive cough to a cough that is more productive and less frequent.

PHARMACOKINETIC PROPERTIES OF GUAIFENESIN

Guaifenesin is well absorbed from the gastro intestinal tract following oral administration. Guaifenesin has a plasma half-life of approximately 1 hour. It is rapidly hydrolyzed (60% within seven hours) and then excreted in the urine, with beta-(2-methoxyphenoxy)-lactic acid as its major urinary metabolite.

PHARMACODYNAMIC PROPERTIES OF DEXTROMETHORPHAN HBR

Dextromethorphan hydrobromide is a cough suppressant which has a central action on the cough centre in the medulla. It has no analgesic properties and little sedative activity.

PHARMACOKINETIC PROPERTIES OF DEXTROMETHORPHAN HYDROBROMIDE

Dextromethorphan hydrobromide is well absorbed from the gastrointestinal tract.
Dextromethorphan undergoes rapid and extensive first-pass metabolism in the liver after oral administration. Genetically controlled O-demethylation (CYD2D6) is the main determinant of dextromethorphan pharmacokinetics in human volunteers.
It appears that there are distinct phenotypes for this oxidation process resulting in highly variable pharmacokinetics between subjects.
Unmetabolised dextromethorphan, together with the three demethylated morphinan metabolites dextrorphan (also known as 3-hydroxy-N-methylmorphinan), 3- hydroxymorphinan and 3-methoxymorphinan have been identified as conjugated products in the urine.
Dextrorphan, which also has antitussive action, is the main metabolite. In some individuals metabolism proceeds more slowly and unchanged dextromethorphan predominates in the blood and urine.
Shake well before use. Avoid over medication.
Hypersensitivity to any ingredient of the product.
Dizziness, dry mouth, G.I disturbances may occur. Excitation, confusion and respiratory depression may occur after overdose.
Store in a cool and dry place.
Protect from direct sunlight.