Aceclofenac and paracetamol Suspension

Aceclofenac has been shown to have potent analgesic and ant inflammatory activities used to treat various painful inflammatory conditions. Aceclofenac has an outstanding anti-inflammatory profile mediated primarily through inhibition of cyclooxygenase (COX) activity and suppression of PGE2 synthesis.
Paracetamol is a safe and effective analgesic-antipyretic agent with minimal effect on Cardiovascular , respiratory and GI system. Paracetamol is a widely used over-the-counter analgesic and antipyretic.
It has been demonstrated by recent studies of INTERNATIONAL JOURNAL OF PHARMACY & LIFE SCIENCES that administration of combination (aceclofenac + paracetamol suapension) possesses remarkable anti-inflammatory, Analgesic and antipyretic properties.

The combination of Aceclofenac and Paracetamol Syrup is also Used in the Management of More Severe Pain (Such as Postoperative Pain):-

• Pain and Inflammation
• Injury
• Dental Pain
• Back Pain
• Arthritis
• Spondylitis
• Inflammatory conditions of ear, nose & throat.

Pharmacokinetics

Absorption:-Aceclofenac: Rapidly absorbed; almost 100% bioavailability; peak plasma levels reached about 1.25-3 hours after oral admin.
Distribution:-Aceclofenac:>99.7% bound to plasma proteins; distributes into synovial fluid.
Paracetamol: Distributes throughout most fluids of the body.
Metabolism:- Aceclofenac:Probably metabolized by CYP2C9; average plasma elimination half-life: 4-4.3 hours.
Paracetamol: Mainly metabolized hepatically; plasma elimination half-life: 1-4 hours.
Excretion:-Aceclofenac: About two-thirds of the administered dose is removed in the urine, mainly as conjugated hydroxymetabolites.
Paracetamol: Most metabolites are removed in the urine within 24 hours.

Paracetamol:- Increased risk of liver damage in chronic alcoholics. Increased risk of toxicity with high doses or long term administration of carbamazepine, hydantoins, isoniazid, rifampin and sulfinpyrazone.

The Most Commonly Reported Adverse Effects are:

• Nausea allergic reactions
• Skin rashes
• Headache
• Diarrhea

Store in a well closed container in cool, dry place, away from direct heat and light.